DL-LEUCINE BIOSYNTH
DL-Leucine
CAS: 328-39-2
Molecular Formula: C6H13NO2
DL-LEUCINE BIOSYNTH - Names and Identifiers
| Name | DL-Leucine |
| Synonyms | DL-Leu leucine,dl DL-Leucine Leucine, DL- DL-LEUCINE BIOSYNTH A-AMINO-ISO-CAPROIC ACID 2-Amino-4-methylvalericacid DL-2-Amino-4-methylpentanoic acid (R,S)-2-Amino-4-methyl-pentanoicacid |
| CAS | 328-39-2 |
| EINECS | 206-328-2 |
| InChI | InChI=1/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9) |
DL-LEUCINE BIOSYNTH - Physico-chemical Properties
| Molecular Formula | C6H13NO2 |
| Molar Mass | 131.17 |
| Density | 1,293 g/cm3 |
| Melting Point | 293-296 °C (subl.) (lit.) |
| Boling Point | 225.8±23.0 °C(Predicted) |
| Specific Rotation(α) | [α]D20 -3.0～+3.0゜ (c=4, HCl) |
| Flash Point | 90.3°C |
| Water Solubility | soluble |
| Solubility | 1 M HCl: soluble |
| Vapor Presure | 0.0309mmHg at 25°C |
| Appearance | White powder |
| Color | White |
| Merck | 14,5451 |
| BRN | 636005 |
| pKa | pKa: 9.744(25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.4630 (estimate) |
| MDL | MFCD00063087 |
| Physical and Chemical Properties | melting point 293-296°C water-soluble solution |
| Use | Used as a nutritional agent in medicine, also used in biochemical research, etc |
DL-LEUCINE BIOSYNTH - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29224995 |
DL-LEUCINE BIOSYNTH - Reference
| Reference Show more | 1. Ma Chang Zhong, Luo Zhang, Gu snow Dong. Analysis and Evaluation of nutritional components of Boletus from Linzhi brick red cashmere cover [J]. Food Science, 2016, 37(024):124-129. 2. [IF = 5.833] Yang Xu et al.. "Microchim Acta. 2019 Apr;186(4):1-8 3. [IF = 4.759] Jingtang Li et al." Synthesis and application of ionic liquid functionalized β-cyclodextrin, mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-β-cyclodextrin chloride, as chiral selector in capillary electrophoresis."J Chromatogr A. 2018 Jul;1559:178 4. [IF=4.556] Dandan Zhao et al."Physico-chemical properties and free amino acids profiles of six wolfberry cultivars in Zhongning."J Food Compos Anal. 2020 May;88:103460 5. [IF=4.379] Feng Lin et al."Chemical profile changes during pile fermentation of Qingzhuan tea affect inhibition of α-amylase and lipase."Sci Rep-Uk. 2020 Feb;10(1):1-10 6. [IF=4.35] Xiaomei Dai et al."1-Methylcyclopropene Preserves the Quality of Chive (Allium schoenoprasum L.) by Enhancing Its Antioxidant Capacities and Organosulfur Profile during Storage."Foods. 2021 Aug;10(8):1792 7. [IF=3.361] Ning Zhao et al."Ratiometric fluorescence probe of Cu2 and biothiols by using carbon dots and copper nanoclusters."Rsc Adv. 2021 Oct;11(53):33662-33674 |
DL-LEUCINE BIOSYNTH - Introduction
Sweet. Can sublimate. Solubility in water (g/L): 7-97 at 0 ℃, 9-91 at 25 ℃, 14-06 at 50 ℃, 22-76 at 75 ℃ and 42-06 at 100 ℃. Solubility in 90% ethanol (g/L): 1.3. Insoluble in ether.
Last Update：2022-10-16 17:24:37
DL-LEUCINE BIOSYNTH - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| identification test | take 0.1% sample liquid 5m!, Add lml of ninhydrin test solution (TS-250) and appear red-purple or blue-purple. |
| content analysis | accurately weigh the sample about 400mg, dissolved in 3ml of formic acid and 50ml of glacial acetic acid. After adding 2 drops of crystal violet test solution (TS-74), titrate with 0.1mol/L perchloric acid until pure green for the first time or blue completely disappears. 0.1mol/I per Ml. Perchloric acid is equivalent to DL-leucine (C6H13NO2)13.12mg. |
| toxicity | LD506429mg/kg (rat, subcutaneous). |
| use | for biochemical research. It is used as a nutritional agent in medicine, and also used in biochemical research. It is used as a nutritional supplement for biochemical research. |
| production method | 2-bromo -4-methylpentanoic acid and concentrated ammonia water are mixed, placed at room temperature for 7 days, and the crude product obtained by filtration is decolorized and refined to obtain the finished product. Yield 43-45%. using isobutyl nitrile acetic acid as raw material, hydrolysis in the presence of sulfuric acid to obtain amide, after crystallization and washing, it is treated with sodium hypobromite to remove carbon dioxide to obtain crude product, and recrystallize to obtain pure product. It is obtained by reacting isobutyl nitrile acetic acid with concentrated sulfuric acid and then treated with bromine. |
Last Update：2024-04-09 20:13:35
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